DNA-Compatible Synthesis of β-Ketoamides as Intermediates for On-DNA Chemical Diversification
Abstract
The β-ketoamide motif represents both a privileged scaffold and a versatile synthetic intermediate in medicinal chemistry. Herein, we developed a DNA-compatible method for the efficient conversion of various DNA-conjugated amines into β-ketoamides. The resulting β-ketoamides facilitate rapid diversification into a panel of structurally diverse molecular scaffolds. Importantly, the synthetic route and subsequent derivatization steps were validated to be fully compatible with DNA encoding, offering a reliable and versatile platform for DNA-encoded library synthesis.
Fields of Study & Subjects
Chemical Synthesis and Analysis
Cyclopropane Reaction Mechanisms
DNA and Nucleic Acid Chemistry
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 9
- Pages
- 3096–3100
- Publication date
- 23 February 2026
- Language
- EN