Visible-Light Photoredox Synthesis of Chroman-4-ones from Sulfoxonium Ylides
Abstract
Organic chroman-4-ones are valuable structural motifs, yet many existing synthetic routes rely on harsh conditions or generate toxic byproducts. Here we report a mild and environmentally compatible visible-light method that employs sulfoxonium ylides as α-carbonyl radical precursors. The reaction proceeds through photoredox activation combined with a radical propagation pathway, enabling efficient radical cascade cyclization with 2-(allyloxy)benzaldehydes. This protocol avoids unstable halogenated reagents, produces only benign byproducts, and provides broad access to chroman-4-one derivatives under ambient conditions.
Fields of Study & Subjects
Radical Photochemical Reactions
Sulfur-Based Synthesis Techniques
Click Chemistry and Applications
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 8
- Pages
- 2807–2812
- Publication date
- 16 February 2026
- Language
- EN