Palladium-Catalyzed Late-Stage Alkenylation of Aryl Fluorosulfonates and Phenol-Containing Drugs

Organic Letters 2026

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Authors: Jingwen Xi, Haoyu Cheng, Yu Meng, Mingxia Wu, Yanfang Shang, Xin‐Xing Wu
DOI: 10.1021/acs.orglett.6c00522
Cited by: 2
References: 34

Abstract

A modular palladium-catalyzed alkenylation of a number of aryl fluorosulfonates and phenol-containing drugs such as estrone, pterostilbene, 6-hydroxyflavone, and other phenol-based pharmaceuticals has been developed. This method enables economical and chemoselective alkenylation of aryl fluorosulfonates with N -tosylhydrazones even in the presence of chloro functionalities, achieving high yields and excellent functional group compatibility. The strategy demonstrates broad application potential in the fields of pharmaceutical and agricultural chemical synthesis.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Catalytic Cross-Coupling Reactions Fluorine in Organic Chemistry

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
13
Pages
4043–4047
Publication date
23 March 2026
Language
EN