Synthesis of Axially Chiral Styrenes via Pd-Catalyzed Atroposelective C–H Olefination

Organic Letters 2026

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Authors: Jiayi Bi, Fei Yao, Xu Wu, Ya Gao, Xue-Tao Xu, Tao Zhou, Bing-Feng Shi
DOI: 10.1021/acs.orglett.6c00525
Cited by: 1
References: 82

Abstract

The synthesis and application of new axially chiral skeletons have always been an attractive and important topic in synthetic chemistry. Herein, we developed a Pd(II)-catalyzed atroposelective C–H olefination for the synthesis of axially chiral styrene with N, N -disubstituted amide groups. A broad range of axially chiral styrenes were obtained in good to excellent yields and enantioselectivities (up to 80% yield and 95% ee) under mild conditions. Gram-scale reaction and further transformation reactions also provide a platform for synthetic applications of this method.

Fields of Study & Subjects

Axial and Atropisomeric Chirality Synthesis Catalytic C–H Functionalization Methods Asymmetric Synthesis and Catalysis

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
15
Pages
4668–4673
Publication date
7 April 2026
Language
EN