Electrochemical N-Centered Radical Cyclization of Aryl Propargyl Alcohols toward Quinolines

Organic Letters 2026

View at publisher
Authors: Qianlong Zhang, Na Li, Anzhou Wang, Qiang Huang, Hongji Li
DOI: 10.1021/acs.orglett.6c00529
Cited by: 1
References: 43

Abstract

We describe here an electrochemically driven cyclization of aryl propargyl alcohols that proceeds without any toxic metal reagents or external chemical oxidants, delivering a range of substituted quinolines in moderate to good yields. This electrochemical protocol offers a practical alternative to rapid quinoline construction. Control and mechanistic studies support the generation of an N -centered radical as the key species initiating the cyclization and C–O bond cleavage, enabling aromatization.

Fields of Study & Subjects

Radical Photochemical Reactions CO2 Reduction Techniques and Catalysts Catalytic Cross-Coupling Reactions

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
16
Pages
5027–5031
Publication date
9 April 2026
Language
EN