Sustainable Synthesis of N -Substituted Pyrroles via Fe-Catalyzed One-Pot Multicomponent Reaction

Organic Letters 2026

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Authors: Santana Chakraborty, Arijit Singha Mohapatra, Nanda D. Paul
DOI: 10.1021/acs.orglett.6c00539
Cited by: 3
References: 62

Abstract

-substituted pyrroles from readily accessible feedstocks, such as alcohols, diols, and amines, catalyzed by a well-defined Fe(II)-catalyst featuring a redox-active azo-aromatic-1,10-phenanthroline-based ligand. Compared to existing approaches, this protocol enables access to diverse pyrrole derivatives, including penta-substituted pyrroles and complex polycyclic frameworks in good yields with improved atom economy and broad functional-group tolerance.

Fields of Study & Subjects

Synthesis and Characterization of Pyrroles Catalytic C–H Functionalization Methods Covalent Organic Framework Applications

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
12
Pages
3808–3813
Publication date
16 March 2026
Language
EN