Highly Regio- and Enantioselective Catalytic 1,6-Conjugate Addition of Grignard Reagents to Cyclic Dienones

Organic Letters 2026

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Authors: Jing-Dong Zhang, Yong Li, Dongmei Yao, Ying Liu, Kang Cai, You‐Cai Xiao, Fen-Er Chen
DOI: 10.1021/acs.orglett.6c00561
Cited by: 1
References: 40

Abstract

. Chiral 2-styryl chromanone and its analogues were produced in high to excellent yields, excellent regioselectivities, and excellent enantioselectivities (82-99% ee's) with a broad substrate scope. This study expands the asymmetric 1,6-conjugate addition of Grignard reagents from linear dienones to more challenging cyclic dienones, and gram-scale reactions further demonstrate the practical applicability of this protocol.

Fields of Study & Subjects

Asymmetric Synthesis and Catalysis Catalytic C–H Functionalization Methods Catalytic Cross-Coupling Reactions

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
16
Pages
5044–5049
Publication date
9 April 2026
Language
EN