Zinc-Mediated Four-Component Carbonylation toward Direct Synthesis of α-Amino Ketones
Abstract
α-Amino ketone plays an important role in medicinal chemistry due to its excellent multiple reaction sites, which serve as a chemical hub for constructing complex molecules. Moreover, its skeleton is also found in many bioactive molecules. The traditional methods for synthesizing α-amino ketones are usually limited by harsh reaction conditions and the use of presynthesized and toxic reagents. As a readily available synthetic reagent, organic iodides play an important role in organic synthesis due to their high reactivity and high functional group compatibility. Herein, we report a zinc-mediated carbonylation reaction involving alkyl iodides, aldehydes, and amines, which efficiently synthesized a series of α-amino ketone compounds.
Fields of Study & Subjects
Carbon dioxide utilization in catalysis
Catalytic Cross-Coupling Reactions
Catalytic C–H Functionalization Methods
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 10
- Pages
- 3366–3370
- Publication date
- 3 March 2026
- Language
- EN