Humupulusones A and B, Two Skeletally Novel Acylphloroglucinol Derivatives from Humulus lupulus

Organic Letters 2026

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Authors: HuaQiang LI, Siqi Li, Gang Li, Na Yang, Jingjin Bai, Jiacheng Weng, Yuben Qiao, Qi Shi, Guifen Zhou, Lina Ji, Chengjian Zheng, Zhengxi Hu
+1 more Luping Qin
DOI: 10.1021/acs.orglett.6c00611
Cited by: 3
References: 33

Abstract

Two novel acylphloroglucinol derivatives, humupulusones A and B ( 1 and 2 ), were isolated from Humulus lupulus . Compound 1, a pair of enantiomers ( 1a / 1b ), is the first acylphloroglucinol derivative with a bicyclo[2.2.2] carbon skeleton possessing a novel 5/6/6/5/5 ring system. Humupulusone B ( 2 ), a pair of hemiacetal tautomers, features a highly rearranged 5/6/5-fused tricyclic scaffold. Moreover, 1a and 2 exhibited significant inhibitory effects on LPS-induced NO production in BV-2 cells with IC 50 values of 13.55 and 16.09 μM, respectively.

Fields of Study & Subjects

Hops Chemistry and Applications Natural Compound Pharmacology Studies Protein Tyrosine Phosphatases

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
12
Pages
3838–3842
Publication date
13 March 2026
Language
EN