Reductive [3 + 2] Annulation of Quinolines and Epoxides for Access to Fused 1,3-Oxazolidines by a Co-Catalyst System
Abstract
Employing the synergistic Ir-SAs@B-ZrO 2 /SiO 2 and (C 6 F 5 ) 3 B catalytic system with PhSiMe 2 H as the reductant, we herein report a new reductive annulation reaction between quinolines and epoxides. This transformation exhibits broad substrate and functional group compatibility, good iridium catalyst reusability, and high step economy. It provides a practical route for directly constructing N-heterocycle-fused 1,3-oxazolidines from readily available starting materials, surpassing conventional methods in both efficiency and sustainability. The present strategy, which merges partial hydro-dearomatization with in situ intermediate transformation, is anticipated to inspire further development of valuable synthetic transformations.
Fields of Study & Subjects
Catalytic C–H Functionalization Methods
Organoboron and organosilicon chemistry
Catalytic Cross-Coupling Reactions
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 16
- Pages
- 5057–5062
- Publication date
- 9 April 2026
- Language
- EN