Site-Selective Decarboxylative C–H Carbenoid Functionalization Enabled by Pyridotriazole-3-carboxylates
Abstract
This paper describes a decarboxylative C–H carbenoid functionalization of (hetero)aryl carboxylic acids by using pyridotriazoles as the carbene precursors, which overcomes the limitation of ester group retention in conventional reactions, enabling the construction of diverse aza-tricyclic structural frameworks via a decarboxylative process. This method successfully overcomes the strong coordinative interference of L-type N -heterocycles with the metal catalyst, thereby allowing for highly site-selective C–H functionalization of (hetero)aryl acids.
Fields of Study & Subjects
Cyclopropane Reaction Mechanisms
Catalytic C–H Functionalization Methods
N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
Publication details
- Journal / source
- Organic Letters
- Volume
- 28
- Issue
- 12
- Pages
- 3843–3849
- Publication date
- 12 March 2026
- Language
- EN