Visible-Light-Induced Copper-Catalyzed Coupling Reaction of Aryl Halides with Phenols at Room Temperature

Organic Letters 2026

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Authors: Xiantong Yao, Qinghua Zhong, Xin Yang, Wenhui Huang, Ziqi Fang, Ruihua Cheng, Yueyue Ma, Jinxing Ye
DOI: 10.1021/acs.orglett.6c00657
Cited by: 1
References: 36

Abstract

This work describes a visible-light-induced Ullmann C-O coupling between aryl halides and phenols at room temperature without an external photocatalyst. Preliminary mechanistic studies suggest that the in situ-formed LCu(I)-phenoxide complex functions as both a photosensitizer and an active catalyst. The synthetic utility of this photoinduced Ullmann-type coupling was demonstrated by a gram-scale reaction with maintained high yield and successful late-stage functionalization of pharmaceutically relevant compounds in good yields.

Fields of Study & Subjects

Catalytic Cross-Coupling Reactions Radical Photochemical Reactions Sulfur-Based Synthesis Techniques

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
18
Pages
5686–5692
Publication date
24 April 2026
Language
EN