Enantio- and Regioselective Access to Chiral α-Amino Ketones via Nickel/Photoredox Catalysis
Abstract
A novel nickelaphotoredox platform enables highly enantio- and regioselective carboacylation of alkenes with alkyl boronate salts and acyl chlorides for the modular asymmetric synthesis of α-amino ketone derivatives. This redox-neutral protocol features a broad substrate scope and scalability and enables ready transformation into valuable chiral synthons and bioactive molecules. Mechanistic studies were undertaken to elucidate the reaction pathway of this alkene difunctionalization.
Fields of Study & Subjects
Radical Photochemical Reactions
Asymmetric Hydrogenation and Catalysis
Cyclopropane Reaction Mechanisms
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 11
- Pages
- 3600–3605
- Publication date
- 4 March 2026
- Language
- EN