Spiropenicitrinol A: A Spirocyclic Polyketide from Penicillium citrinum with Potent Anti-inflammatory Activity

Organic Letters 2026

View at publisher
Authors: Zhetong Liu, Tao Yang, Xiaozhi Huang, Qing Rong Qi, Chending Luo, Nan Wang, Yujiao Shu, Haitian Zhang, Guanqun Zhan, Zengjun Guo
DOI: 10.1021/acs.orglett.6c00687
Cited by: 2
References: 27

Abstract

Spiropenicitrinol A ( 1 ), an intriguing 5/5/6/5 spirocyclic polyketide architecture with a unique 3 H -spiro[benzo[1,2- b:4,5- b ′]difuran-2,1′-cyclopentane] core, was obtained from Penicillium citrinum Y12. The structure was established by spectroscopic analysis, quantum-chemical calculations, and single-crystal X-ray crystallography. 1 showed potent anti-inflammatory activity by inhibiting LPS-induced NO, TNF-α, IL-6, and IL-1β production in RAW264.7 cells. These findings indicated that this complex spirocyclic architecture could serve as a promising scaffold for the further development of novel anti-inflammatory agents.

Fields of Study & Subjects

Microbial Natural Products and Biosynthesis Peptidase Inhibition and Analysis Microbial Metabolism and Applications

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
14
Pages
4457–4461
Publication date
1 April 2026
Language
EN