Photoinduced Dearomative Oxyimination of Indoles Using Oxime Esters as Bifunctional Radical Precursors
Abstract
A photoinduced, metal-free, and regioselective oxyimination of indole derivatives has been developed, enabling efficient difunctionalization via simultaneous C-O and C-N bond formation. Using oxime esters as dual radical precursors, this mild and sustainable strategy achieves a high atom economy and excellent diastereoselectivity. It can be applied to benzofuran and benzothiophene derivatives. This method provides a versatile and practical approach for dearomative transformations, offering new opportunities for the diastereoselective functionalization of indole derivatives.
Fields of Study & Subjects
Radical Photochemical Reactions
Catalytic C–H Functionalization Methods
Oxidative Organic Chemistry Reactions
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 11
- Pages
- 3612–3618
- Publication date
- 5 March 2026
- Language
- EN