Construction of Functionalized 2,3-Dihydropyrroles via Visible-Light-Driven Formal [3 + 2] Cycloaddition

Organic Letters 2026

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Authors: Sheng-Sheng Yin, S. M. Chen, Yue-Liu-Ting Fu, Liang-Qiu Lu, Caixian Yan, Ying Cheng, Qiaowen Chang, Wen-Jing Xiao
DOI: 10.1021/acs.orglett.6c00702
Cited by: 2
References: 63

Abstract

In recent years, a photoredox catalysis strategy has emerged as a powerful platform for generating open-shell intermediates under mild conditions, enabling the development of novel radical-based transformations that are difficult to achieve via traditional ionic pathways. Among these, radical-mediated cyclization reactions allow for the rapid and modular assembly of complex molecular scaffolds. Herein, we report a visible-light-driven formal [3 + 2] cycloaddition reaction of electron-deficient 1,3-conjugated enynes and α-silylamines. This reaction provides a practical route to highly functionalized 2,3-dihydropyrroles under mild and redox-neutral conditions with operational simplicity and a broad substrate scope.

Fields of Study & Subjects

Radical Photochemical Reactions Catalytic C–H Functionalization Methods Photochromic and Fluorescence Chemistry

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
13
Pages
4175–4181
Publication date
25 March 2026
Language
EN