Pd-Catalyzed Annulation of Aryl Iodides with Ynamides for the Synthesis of 9-Aminophenanthrenes: Regioselectivity in Reductive Elimination of Pallada(IV)cycle
Abstract
This work describes an efficient Pd-catalyzed three-component annulation process of aryl iodides and ynamides. A wide variety of 9-aminophenanthrenes bearing various functional groups can be obtained in up to 94% yield. The reaction likely proceeds via a 3-amino-substituted pallada(IV)cycle through sequential reaction processes. It appears that the formation of the aryl-vinyl bond is preferred over the aryl-aryl bond during the reductive elimination of the pallada(IV)cycle.
Fields of Study & Subjects
Catalytic Alkyne Reactions
Catalytic Cross-Coupling Reactions
Catalytic C–H Functionalization Methods
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 14
- Pages
- 4500–4506
- Publication date
- 28 March 2026
- Language
- EN