Photocatalytic [4 + 1] Annulation of Vinyl Aziridines with Alkyl Halides

Organic Letters 2026

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Authors: Dan Wang, Xintao Liu, Jinghan Zhang, Jingjing Zhao, Pan Li
DOI: 10.1021/acs.orglett.6c00743
Cited by: 9
References: 56

Abstract

Herein, we develop a photocatalytic [4 + 1] annulation of vinyl aziridines with alkyl halides. The reaction appears to experience radical trigger kinetically favored β-scission of the vinyl aziridine C-N bond, generating transient nitrogen-centered radical, followed by sequential single electron oxidation, 5-exo-trig cyclization, and protonation. Significantly, an unprecedented annulation mode in which vinyl aziridines serve as four-atom synthons has been disclosed.

Fields of Study & Subjects

Radical Photochemical Reactions Catalytic C–H Functionalization Methods Synthesis and Catalytic Reactions

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
13
Pages
4201–4207
Publication date
23 March 2026
Language
EN