Palladium-Catalyzed Tandem Synthesis of Fused Spiroquinolinones from Bicyclobutyl Amides
Abstract
A palladium-catalyzed tandem cyclization and amination of bicyclobutyl (BCB) amides has been disclosed for the assembly of fused spiroquinolinone skeletons. By using di- t -butyldiaziridinone as the amination reagent, the reaction of bicyclobutyl amides with perfluoroalkyl iodides proceeded efficiently to furnish a broad range of fused spiroquinolinone derivatives in high yields. Notably, this strategy enables the rapid incorporation of a fused ring at the 4,5,10-position and a spiro ring at the 3-position of the quinolinone core.
Fields of Study & Subjects
Catalytic C–H Functionalization Methods
Catalytic Cross-Coupling Reactions
Synthesis and pharmacology of benzodiazepine derivatives
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 12
- Pages
- 3890–3894
- Publication date
- 17 March 2026
- Language
- EN