Metal-Free Photoredox-Catalyzed Anti-Markovnikov Phosphinothiolation of Styrenes: Chemodivergent Access to S -Alkyl-phosphinothioates and β-Keto-phosphinothioates

Organic Letters 2026

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Authors: Souvik Roy, Saloni Kumari, Saira Banu, Krishnendu Halder, Priyanka Mukhopadhyay, Sabuj Kundu
DOI: 10.1021/acs.orglett.6c00747
Cited by: 4
References: 32

Abstract

Anti-Markovnikov hydrophosphinothiolation of alkenes is quite challenging and is rarely explored. Herein, we report a visible-light-mediated metal-free multicomponent coupling strategy for the anti-Markovnikov hydrophosphinothiolation of styrenes, utilizing readily accessible phosphine-oxides and elemental sulfur. This operationally simple protocol delivers a broad range of S -alkyl-phosphinothioates with excellent selectivity and atom economy. Fine-tuning the reaction parameters tweaks the pathway to afford β-keto-phosphinothioates, expanding the synthetic utility of this transformation to access chemodivergent products.

Fields of Study & Subjects

Sulfur-Based Synthesis Techniques Organophosphorus compounds synthesis Radical Photochemical Reactions

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
12
Pages
3895–3900
Publication date
17 March 2026
Language
EN