Tetrasargltones A and B, Fully Helically Polymerized Lindenane Sesquiterpenoid Tetramers from Sarcandra glabra
Abstract
Tetrasargltones A and B ( 1 and 2, respectively), representing the first examples of lindenane sesquiterpenoid (LS) tetramers, were isolated from Sarcandra glabra . Their structures were fully elucidated via HR-MS and NMR, with their authenticity further confirmed by X-ray diffraction. Structurally, 1 and 2 possess two unprecedented fully helically polymerized carbon skeletons, which are formed through plausible sequential Diels–Alder cycloadditions at different sites of the triene LS precursor. Biologically, 1 and 2 exhibit cytotoxic activity against five cancer cell lines, with 2 showing the best activity in HCT116 cells (IC 50 = 2.51 ± 0.13 μM) and exerting its cytotoxic effects through NF-κB pathway inhibition.
Fields of Study & Subjects
Sesquiterpenes and Asteraceae Studies
Plant-derived Lignans Synthesis and Bioactivity
Natural Compound Pharmacology Studies
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 12
- Pages
- 3885–3889
- Publication date
- 16 March 2026
- Language
- EN