Base-Promoted Cascade Multicomponent Access to Azatrithiathiophthenes from Cinnamonitriles, Sulfur and Active Methylhetarenes

Organic Letters 2026

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Authors: Minh Tu Ha, M. T. Vu, Yen Le, Thu Trang Pham, Thaï Thanh Thu Bui, Quoc Nghi Pham, Dinh Hung Mac, Le Anh Nguyen, Pascal Retailleau, Thanh Binh Nguyen
DOI: 10.1021/acs.orglett.6c00769
Cited by: 6
References: 37

Abstract

A new approach for synthesizing polysulfa fused azatrithiathiophthene heterocycles was developed based on multiple C-H functionalization of diverse active methyl hetarenes and cinnamonitriles with elemental sulfur. This multicomponent reaction afforded a series of novel azatrithiathiophthenes bearing a tetravalent sulfur atom in the junction of two fused heterocycles.

Fields of Study & Subjects

Sulfur-Based Synthesis Techniques Catalytic C–H Functionalization Methods Synthesis of heterocyclic compounds

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
15
Pages
4725–4729
Publication date
3 April 2026
Language
EN