Photocatalytic anti-Markovnikov Chloroalkynylation of Unactivated Alkenes

Organic Letters 2026

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Authors: Yun-Kai Wang, Xinyu Yang, Jin Zhou, Ren-Jie Tong, Peng-Hui Shen, Rui-Qiang Xu, Jun Xu, Hua‐Jian Xu
DOI: 10.1021/acs.orglett.6c00775
Cited by: 1
References: 58

Abstract

A photoinduced three-component anti-Markovnikov chloroalkynylation of unactivated alkenes is enabled by proton-coupled electron transfer (PCET) using bench-stable HCl and alkynyl sulfones. A neutral acridine photocatalyst promotes cascade radical addition/fragmentation under mild conditions, delivering highly regioselective products otherwise difficult to access. The method accommodates diverse unactivated alkenes, including alkyl-substituted, 1,1-disubstituted, and drug-like derivatives. Diverse downstream derivatizations highlight the synthetic utility of these chloroalkyne building blocks.

Fields of Study & Subjects

Radical Photochemical Reactions Catalytic C–H Functionalization Methods Sulfur-Based Synthesis Techniques

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
15
Pages
4741–4747
Publication date
8 April 2026
Language
EN