Dynamic Kinetic Resolution Enabled Synthesis of Planar and Central Chiral Ferrocenes

Organic Letters 2026

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Authors: Shilpi Bhardwaj, Devendra Parganiha, Vishal Choudhary, Ashwini Dilip Dhumale, Sangit Kumar
DOI: 10.1021/acs.orglett.6c00779
Cited by: 1
References: 43

Abstract

Ferrocene scaffolds with planar and central chirality are privileged motifs in enantioselective catalysis. Herein, we disclose a dynamic kinetic resolution (DKR) strategy in which chiral allenes enable consecutive axial-to-planar and axial-to-central chirality transfer, allowing the construction of planar and central chiral ferrocenes in up to 80% yield and 96% ee.

Fields of Study & Subjects

Axial and Atropisomeric Chirality Synthesis Synthesis and Properties of Aromatic Compounds Asymmetric Synthesis and Catalysis

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
15
Pages
4735–4740
Publication date
6 April 2026
Language
EN