Visible-Light-Driven ( E )-β-Trifluoromethylation of Enamides via In Situ Generated Sulfur(VI) Photosensitizers

Organic Letters 2026

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Authors: Caiwen Wan, Changtong Shao, Ruolan Leng, Rui Yang, Dingfeng Yang, Jie Gao, Yixi Bao, Yuanxue Yi, Yuanyuan Li
DOI: 10.1021/acs.orglett.6c00782
Cited by: 8
References: 36

Abstract

We report an autoinductive, visible-light-mediated ( E )-β-trifluoromethylation of enamides using sodium trifluoromethanesulfinate. This protocol eliminates exogenous catalysts by leveraging an in situ generated pentacoordinate sulfur(VI) species as the photosensitizer. Characterized by mild conditions and broad substrate compatibility, the method exhibits promising scalability, as evidenced by a gram-scale continuous-flow synthesis. This oxidant- and catalyst-free strategy provides a robust, scalable paradigm for accessing valuable trifluoromethylated building blocks.

Fields of Study & Subjects

Fluorine in Organic Chemistry Radical Photochemical Reactions Sulfur-Based Synthesis Techniques

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
12
Pages
3918–3923
Publication date
17 March 2026
Language
EN