Construction of α-Acyl-β-amino Amides via Multicomponent Reactions of β-Acyloxy Alkenyl Amides with Amines and Aldehydes
Abstract
Herein, we describe a novel multicomponent synthesis of α-acyl-β-amino amides with structural diversity and brevity from aldehydes, amines, and β-acyloxy alkenyl amides (AAAs). In this multicomponent protocol involving fragmentation and reassembly processes, AAAs act as the key building blocks for the construction of the β-amino amides simply via acid promotion, providing a step- and atom-economical approach to access these useful products with excellent diastereoselectivity.
Fields of Study & Subjects
Advanced Synthetic Organic Chemistry
Chemical Synthesis and Analysis
Multicomponent Synthesis of Heterocycles
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 13
- Pages
- 4234–4239
- Publication date
- 19 March 2026
- Language
- EN