Electrochemical Synthesis of Benzotriazoles and Benzotriazinones
Abstract
Benzotriazoles and benzotriazinones are pivotal N -heterocycles in organic synthesis, drug discovery, and materials science. Herein, we present a safe electrochemical strategy that directly transforms 2-nitroanilines and 2-nitrobenzamides into these heterocycles through in situ nitro reduction and diazotization. By precisely tuning the redox potentials and employing suitable electrodes, unstable diazonium intermediates are generated and consumed in a controlled manner, avoiding their over-reduction. This approach offers a scalable synthetic route directly from nitro precursors.
Fields of Study & Subjects
Nanomaterials for catalytic reactions
Radical Photochemical Reactions
Quinazolinone synthesis and applications
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 15
- Pages
- 4767–4771
- Publication date
- 1 April 2026
- Language
- EN