Electropositive Sulfur Activation for the Regioselective Amino Functionalization of Alkynyl Sulfonium Salts

Organic Letters 2026

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Authors: Cheng Peng, Qiang Huang, Jinglei Chen, Hong Deng, Hongji Li
DOI: 10.1021/acs.orglett.6c00838
Cited by: 1
References: 44

Abstract

We report an electropositive sulfur activation strategy for regioselective alkyne amination, enabling the tunable amino functionalization of alkynyl sulfonium salts with triazoles under ambient conditions. The operationally simple protocol exhibits a broad substrate scope and excellent functional-group tolerance, delivering vinyl triazoles in moderate to excellent yields. Both the control experiments and the isolation of key intermediates support a stepwise reaction pathway for this chemical process.

Fields of Study & Subjects

Sulfur-Based Synthesis Techniques Radical Photochemical Reactions Advanced Synthetic Organic Chemistry

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
15
Pages
4789–4794
Publication date
2 April 2026
Language
EN