DNA-Compatible Strecker Reaction for the Synthesis of α-Aminonitriles

Organic Letters 2026

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Authors: Danila Ryzhikh, Gyuhwa Cho, Jihoon Lee, Minsoo Song, Gil Tae Hwang
DOI: 10.1021/acs.orglett.6c00840
Cited by: 2
References: 52

Abstract

We report a DNA-compatible synthesis of α-aminonitriles via the Strecker reaction. Systematic optimization of reaction conditions and evaluation of a broad range of aldehydes and aromatic amines revealed high functional-group tolerance, with 68% of the examined substrates affording ≥ 70% conversion. The transformation proceeds under mild conditions that preserve DNA integrity, enabling multicycle split-and-pool library synthesis. This method expands the repertoire of DNA-compatible multicomponent reactions and enables the incorporation of α-aminonitrile scaffolds into DEL platforms.

Fields of Study & Subjects

Advanced Synthetic Organic Chemistry Organic and Inorganic Chemical Reactions Catalytic C–H Functionalization Methods

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
15
Pages
4777–4782
Publication date
1 April 2026
Language
EN