A 6/5/6/5-Fused Indeno[7,1- bc ]furan Diterpenoid Skeleton from Pinus yunnanensis Resins with Anti-Neuroinflammatory and Antidepressant Activities
Abstract
Pinynditerpene A ( 1 ), an unprecedented abietane diterpenoid featuring a unique 6/5/6/5-fused indeno[7,1- bc ]furan skeleton with 5 consecutive chiral centers, was isolated from Pinus yunnanensis resins. Its structure was elucidated by spectroscopic, computational, and crystallographic methods. 1 was found to be able to alleviate inflammation associated depression-like behaviors in mice, exerting its significance in mood disorders.
Fields of Study & Subjects
Biological Activity of Diterpenoids and Biflavonoids
Bioactive Natural Diterpenoids Research
Plant-derived Lignans Synthesis and Bioactivity
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 16
- Pages
- 5097–5101
- Publication date
- 9 April 2026
- Language
- EN