C(sp 3 )–F Bond Functionalization of Isoflurane with Complex Phenols for the Synthesis of CF 2 -Based (Deuterated) Aryl Ethers
Abstract
Defluorination of polyfluorinated aliphatic substances (PFAS) is highly essential due to increasing concerns over PFAS-related environmental issues. In the present study, we demonstrate that commercially available Isoflurane (belongs to PFAS family) can be repurposed as a valuable fluorinated feedstock through selective C(sp 3 )–F bond functionalization. A simple, transition-metal-free protocol converts Isoflurane into a reactive fluoroalkene intermediate that undergoes nucleophilic addition with complex phenols. This strategy provides access to diverse, valuable CF 2 -based ethers bearing an additional chloro handle. The method also enables the preparation of deuterated analogues, expanding the toolkit of fluorinated and deuterated motifs for medicinal chemistry.
Fields of Study & Subjects
Fluorine in Organic Chemistry
Chemical Reactions and Isotopes
Microwave-Assisted Synthesis and Applications
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 14
- Pages
- 4573–4578
- Publication date
- 30 March 2026
- Language
- EN