Marundihomalkins A–J and Marundisphingalkin A: Triglyceride-Lowering Marine Fungal Alkaloids Featuring Non-amide C–N Linkages between Polyketide and Homoisoleucine or Phytosphingosine

Organic Letters 2026

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Authors: Lei Li, Run‐Zhu Fan, Xinxiang Xu, Long Jiang, Yifan Fu, Lu Gan, Sheng Yin, Gui-Hua Tang
DOI: 10.1021/acs.orglett.6c00895
Cited by: 2
References: 19

Abstract

Eleven novel fungal alkaloids, marundihomalkins A–J ( 1 – 10 ) and marundisphingalkin A ( 11 ), featuring unprecedented non-amide C–N linkages between polyketide and homoisoleucine (homo-Ile) or phytosphingosine units, were isolated from the marine-derived fungus Microsphaeropsis arundinis HL1. Their structures, including four skeletal classes, were established by spectroscopic data, X-ray diffraction, and electronic circular dichroism calculations. This work provides the first structural evidence of homo-Ile as a natural biosynthetic building block and reports the inaugural phytosphingosine–polyketide hybrid alkaloid. 11 significantly inhibited adipogenesis in 3T3-L1 cells by PPAR signaling suppression.

Fields of Study & Subjects

Sphingolipid Metabolism and Signaling Microbial Natural Products and Biosynthesis Plant-Microbe Interactions and Immunity

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
15
Pages
4858–4863
Publication date
6 April 2026
Language
EN