Visible Light-Induced Synthesis of Esterified Quinolines and Pyrrolidones Controlled by Different Electrical Anilines

Organic Letters 2026

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Authors: Xiaoyu Pan, Li Zhang, Le Wu, Pengxiang Yin, Ziren Chen, Fei Xue, Bin Wang, Yu Xia, Yonghong Zhang, Shaofeng Wu, Shicheng Dong, Chenjiang Liu
DOI: 10.1021/acs.orglett.6c00898
Cited by: 3
References: 37

Abstract

We report a visible light-induced radical cyclization strategy by in situ formation of 2-(phenylimino)acetates and 2-(phenylamino)fumarates under mild, photocatalyst-free conditions. This operationally simple protocol allows the rapid and divergent assembly of a small library of esterified quinolines and pyrrolidone skeletons (42 examples) with outstanding functional group tolerance, especially for the construction of heteroaroyl/polyaryl-fused quinolines and fluoroalkylated pyrrolidones. Mechanism studies and DFT calculations have verified the in situ generation and transformation process of the dual intermediates.

Fields of Study & Subjects

Radical Photochemical Reactions Photochromic and Fluorescence Chemistry Catalytic C–H Functionalization Methods

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
15
Pages
4829–4835
Publication date
3 April 2026
Language
EN