Visible-Light-Enabled Sulfonyl Radical-Triggered Cyclization Strategy for the Efficient Synthesis of Benzosultams

Organic Letters 2026

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Authors: Mithu Roy, Sanatjit Kar, Masthan Thamim, Anirban Bera, Sudipta Siuli, Debdas Dhabal, Dipankar Srimani
DOI: 10.1021/acs.orglett.6c00908
Cited by: 2
References: 34

Abstract

We introduce a green and practical visible-light-driven method to synthesize benzosultam derivatives using an eosin Y organophotocatalyst. Under ambient conditions, N -alkyl- N -propargyl arylsulfonamides react with sodium aryl sulfinates through a sulfonyl-radical-driven cyclization to produce the corresponding exocyclic benzosultams. Furthermore, these products smoothly isomerize to their endocyclic forms with a mild base. This metal-free approach is mild, versatile, and eco-friendly, providing excellent yields over a wide range of substrates.

Fields of Study & Subjects

Radical Photochemical Reactions Sulfur-Based Synthesis Techniques Catalytic C–H Functionalization Methods

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
13
Pages
4305–4311
Publication date
20 March 2026
Language
EN