Total Synthesis of Isoriccardin C and Isoriccardin D Based on a Hydroxyl-Directed Palladium-Catalyzed Intramolecular C–H Alkenylation

Organic Letters 2026 Open access

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Authors: P. Pasiero Losada, Jose Luis Mascarenas, Moisés Gulías
DOI: 10.1021/acs.orglett.6c00911
Cited by: 1
References: 31

Abstract

-alkenylation that forges the 18-membered macrocyclic core. This streamlined route enables the total synthesis with minimal reliance on protecting groups, and its modular nature offers a versatile platform for the construction of structural analogues.

Fields of Study & Subjects

Synthesis and Biological Activity Catalytic C–H Functionalization Methods Plant-derived Lignans Synthesis and Bioactivity

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
15
Pages
4836–4840
Publication date
6 April 2026
Language
EN