Chemoenzymatic Triazolopyridine Synthesis Enabled by Cryptic Diazo Formation by Vanadium-Dependent Haloperoxidases

Organic Letters 2026 Open access

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Authors: Manik Sharma, Kyle F. Biegasiewicz
DOI: 10.1021/acs.orglett.6c00937
Cited by: 1
References: 61

Abstract

generation of 2-pyridyl ketone hydrazones followed by VHPO-catalyzed oxidative cyclization to give [1,2,3]triazolo[1,5a]pyridines in high yield and chemoselectivity.

Fields of Study & Subjects

Vanadium and Halogenation Chemistry Cyclopropane Reaction Mechanisms Enzyme-mediated dye degradation

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
16
Pages
5108–5113
Publication date
13 April 2026
Language
EN