Highly Enantioselective Hydrogenation of Imines Catalyzed by Chiral Macrocyclic Boranes
Abstract
In this paper, we report a macrocyclic alkene-derived borane catalyst for the asymmetric hydrogenation of imines. A wide range of imines was successfully converted to chiral amines in 80-97% yields and 40-97% ee. The macrocyclic framework is indispensable for excellent catalytic activity and enantioselectivity. A gram-scale reaction with 0.2 mol % catalyst loading achieved a turnover number of 485, the highest reported to date for frustrated Lewis pair-catalyzed asymmetric imine hydrogenation.
Fields of Study & Subjects
Organoboron and organosilicon chemistry
Asymmetric Hydrogenation and Catalysis
Boron Compounds in Chemistry
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 16
- Pages
- 5102–5107
- Publication date
- 10 April 2026
- Language
- EN