Nickel-Photocatalytic Deoxygenative Arylation toward β-Methyl-Branched α-Amino Acids
Abstract
β-Methyl-branched α-amino acids are important motifs in peptide therapeutics. However, only few methods on their synthesis have been reported to date. Herein we report an efficient, one-step synthesis of these β-Me-branched α-amino acids through the deoxygenative arylation of threonine, yielding a diverse scope of noncanonical α-amino acids with good functional group tolerance. Our method could also be extended to the deoxygenative arylation of 3-hydroxyproline, giving access to various therapeutically relevant arylated amino acids.
Fields of Study & Subjects
Radical Photochemical Reactions
Catalytic Cross-Coupling Reactions
Catalytic C–H Functionalization Methods
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 17
- Pages
- 5383–5388
- Publication date
- 20 April 2026
- Language
- EN