Photocatalytic Difluoromethylation Cyclization and Dioxygen Trapping: Access to gem -Difluoro-Quinolines

Organic Letters 2026

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Authors: Lianglong Sun, Xinming Xu, Qiao Li, Zehong Li, Yifan Chen, Qinghao Dong, Si Chen, Xin Wang, Kai Sun
DOI: 10.1021/acs.orglett.6c00972
Cited by: 3
References: 84

Abstract

Herein, a novel photocatalytic 6- exo - trig difluoromethylation cyclization and subsquent domino O 2 trap version is described. This protocol allows efficient access to structurally diverse 4-(hydroxymethyl)- gem -difluoro-quinolines under mild conditions. Broad substrate scope, good functional group compatibility, biologically active molecule modification, scale-up operation, and further derivatization demonstrate the utility of this protocol. A radical cyclization route was proposed based on radical inhibition experiments, deuterium-labeled experiments, visible-light irradiation on–off test, apparent quantum efficiency (AQE) calculation, and Stern–Volmer fluorescence quenching experiments.

Fields of Study & Subjects

Fluorine in Organic Chemistry Radical Photochemical Reactions Catalytic C–H Functionalization Methods

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
13
Pages
4325–4330
Publication date
23 March 2026
Language
EN