Co/Salox-Catalyzed Enantioselective C–H Annulation for One-Step Generation of C–N Axial and C Central Chirality
Abstract
Achieving the formation of multiple chiral centers with complete selectivity in a single-step synthesis continues to be a significant challenge for asymmetric synthesis. Herein, a novel strategy for the Co-catalyzed enantioselective annulation of 4-methyl- N -(quinoline-8-yl)benzamides with the strained bicyclic alkenes has been demonstrated. This catalytic protocol enables double enantioinduction to control the C–N axes with low rotational barriers and carbon central chirality in a one-step synthesis. The developed reaction can be performed either with a metal oxidant or under alternative oxidation conditions such as photoredox catalysis.
Fields of Study & Subjects
Catalytic C–H Functionalization Methods
Axial and Atropisomeric Chirality Synthesis
Cyclopropane Reaction Mechanisms
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 20
- Pages
- 6177–6183
- Publication date
- 12 May 2026
- Language
- EN