Enantioselective Alkylation of Fused Bicyclic Pyridines Enabled by Chiral Lithium Amides as Traceless Auxiliaries

Organic Letters 2026

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Authors: Erika E. Chambers, Leroy Lu, Armen Zakarian
DOI: 10.1021/acs.orglett.6c01018
Cited by: 1
References: 22

Abstract

Pyridines and nitrogen containing heterocycles comprise a large portion of pharmaceutical compounds and have many practical applications. Herein, we describe a straightforward, enantioselective method for direct alkylation of fused bicyclic pyridines, using chiral lithium amides as traceless auxiliaries. This method is tolerant of a variety of activated electrophiles which can allow for further functionalization.

Fields of Study & Subjects

Coordination Chemistry and Organometallics Axial and Atropisomeric Chirality Synthesis Asymmetric Hydrogenation and Catalysis

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
15
Pages
4947–4950
Publication date
2 April 2026
Language
EN