Catalytic Asymmetric Allylation of Cyclopropanols with Allyl Alcohols

Organic Letters 2026

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Authors: Dan Jiang, Hongbing Xiong, Wenliang Zeng, Peng Tang, Qiong Luo, Chenyang Wang, Yi Wu, Min Zhang
DOI: 10.1021/acs.orglett.6c01140
Cited by: 4
References: 53

Abstract

Herein, we report an iridium-catalyzed direct asymmetric ring-opening allylation of cyclopropyl alcohols with free allyl alcohols. The catalytic system, consisting of [Ir(cod)Cl] 2, Carreira phosphoramidite ligand, and Fe(ClO 4 ) 2 · x H 2 O, enables efficient formation of β-allyl-substituted carbonyl compounds in good yields with excellent enantioselectivities (up to >99% ee ). The method exhibits a broad substrate scope, tolerating diverse phenylvinylcarbinol derivatives and both aryl- and alkyl-substituted cyclopropanols.

Fields of Study & Subjects

Asymmetric Synthesis and Catalysis Cyclopropane Reaction Mechanisms Asymmetric Hydrogenation and Catalysis

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
15
Pages
4993–4997
Publication date
3 April 2026
Language
EN