Palladium-Catalyzed Polydeuteration of (Hetero)arenes in Heavy Water Using Indazole–Pyridone Ligands

Organic Letters 2026

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Authors: Sungjun Choi, Chaewon Lim, Soo Eun Park, Siyeon Jeong, Subin Park, Youngsuk Kim, Jung Min Joo
DOI: 10.1021/acs.orglett.6c01143
Cited by: 1
References: 39

Abstract

We report a Pd(II)-catalyzed C–H polydeuteration enabled by a newly designed indazole–pyridone ligand class. These ligands promote (hetero)aromatic sp 2 C–H perdeuteration using inexpensive D 2 O as the deuterium source. Systematic studies revealed a beneficial effect of halogen substituents in the reaction system, suggesting the possible role of noncovalent interactions under aqueous conditions. The method is applicable to a range of (hetero)arenes and enables late-stage deuteration of pharmaceutically relevant molecules with high levels of deuterium incorporation.

Fields of Study & Subjects

Chemical Reactions and Isotopes Catalytic C–H Functionalization Methods Asymmetric Hydrogenation and Catalysis

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
16
Pages
5274–5279
Publication date
9 April 2026
Language
EN