Fe-LMCT Photodecarboxylation for (Hetero)arene Chloro- and Bromodifluoromethylation: Rapid Access to Aromatic Acyl Fluorides
Abstract
X) offer complementary properties to other fluorinated substituents in modulating biological functionality and provide versatile synthetic handles for postfunctionalization. However, their widespread use remains limited by the scarcity of practical halodifluoromethylating reagents. Here, we report a photoinduced Fe-catalyzed strategy that repurposes readily available chloro- and bromodifluoroacetates as traceless radical precursors for (hetero)arene C-H halodifluoroalkylations. The resulting products exhibit broad synthetic versatility, enabling streamlined one-pot access to valuable acyl fluoride synthons.
Fields of Study & Subjects
Fluorine in Organic Chemistry
Radical Photochemical Reactions
Catalytic C–H Functionalization Methods
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 17
- Pages
- 5574–5579
- Publication date
- 20 April 2026
- Language
- EN