SuFEx-Functionalized Pyrroles via Regioselective 1,3-Dipolar Cycloaddition of Münchnones

Organic Letters 2026

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Authors: Jayalakshmi Achath, Malu Biju, Sreejith K. Aravindakshan, Jomon Mathew, Jubi John
DOI: 10.1021/acs.orglett.6c01229
Cited by: 1
References: 40

Abstract

We have devised a regioselective synthesis of sulfonyl fluoride-functionalized pyrroles via the 1,3-dipolar cycloaddition of münchnones with 1-bromoethene-1-sulfonyl fluoride. The methodology was scalable and could realize the synthesis of a wide variety of functionalized pyrroles. By subjecting the sulfonyl fluoride-functionalized pyrroles to SuFEx conditions, we could generate interesting pyrrole sulfonamides and sulfonates.

Fields of Study & Subjects

Synthesis and Characterization of Pyrroles Synthesis and Reactivity of Heterocycles Cyclopropane Reaction Mechanisms

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
15
Pages
5016–5020
Publication date
1 April 2026
Language
EN