Vinylsiloxanes as Alkenylating Agents in Nickel-Catalyzed Difunctionalization of Vinylarenes

Organic Letters 2026 Open access

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Authors: L Salamone, Qihang Tan, Gwilherm Evano, Olivier Riant
DOI: 10.1021/acs.orglett.6c01252
Cited by: 1
References: 42

Abstract

We report the first directing-group-free nickel-catalyzed difunctionalization of vinylarenes using bench-stable vinylsiloxanes as alkenylating agents. This mild, scalable and stereospecific method provides regioselective access to functionalized disubstituted alkenes with broad scope, low catalyst loadings, and minimal Z -isomerization, establishing vinylsiloxanes as versatile alkenyl transfer partners in multicomponent nickel catalysis.

Fields of Study & Subjects

Catalytic Cross-Coupling Reactions Catalytic C–H Functionalization Methods Organoboron and organosilicon chemistry

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
17
Pages
5592–5597
Publication date
21 April 2026
Language
EN