X-Type Silyl Ligand-Controlled Regiodivergent C–H Borylation of Isoquinolines

Organic Letters 2026

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Authors: Song Zhou, Mingyuan Yin, Yi-Xiang Wang, Chaolei Shu, Li Fu, Wanshu Wang, Lu Gao, Zhenlei Song
DOI: 10.1021/acs.orglett.6c01263
Cited by: 1
References: 43

Abstract

An X-type silyl ligand-controlled regiodivergent C–H borylation of isoquinoline has been achieved. The bidentate SiN ligand ( L1 ) favors N-directed C–H borylation on the 1-aryl ring, while the SiNN pincer ligand ( L2 ) facilitates undirected C–H borylation at positions 6 and 7. The t -Bu/Me group on the silyl ligand proves to be the optimal combination to promote the undirected pathway.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Organoboron and organosilicon chemistry Catalytic Cross-Coupling Reactions

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
20
Pages
6226–6231
Publication date
8 May 2026
Language
EN