Dual Photoredox/Nickel-Catalyzed Atroposelective C–N Coupling with Carbazoles and Indoles as N -Nucleophiles

Organic Letters 2026

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Authors: Si‐Jia Liu, Jialiang Yang, Tian‐Zhen Li, Hong‐Hao Zhang, Feng Shi
DOI: 10.1021/acs.orglett.6c01272
Cited by: 3
References: 75

Abstract

Transition metal-catalyzed atroposelective C(sp 2 )–N coupling efficiently constructs valuable (hetero)biaryl scaffolds. However, nickel-catalyzed variants remain underdeveloped, and the use of carbazoles or indoles as N -nucleophiles in such couplings has not been explored. Addressing this, we report a photoredox/Ni-cocatalyzed atroposelective C(sp 2 )–N cross-coupling with carbazoles and indoles. This work establishes the first highly enantioselective metallaphotoredox C(sp 2 )–N bond formation, providing a sustainable route to valuable N -heterobiaryl atropisomers.

Fields of Study & Subjects

Axial and Atropisomeric Chirality Synthesis Polyoxometalates: Synthesis and Applications Catalytic C–H Functionalization Methods

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
18
Pages
5786–5792
Publication date
28 April 2026
Language
EN