Cobalt-Catalyzed Asymmetric Annulative Dienylation with Allenyl Carbinol Acetates via Desymmetrization

Organic Letters 2026

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Authors: Mainak Koner, Suman Ghosh, Mahiuddin Baidya
DOI: 10.1021/acs.orglett.6c01285
Cited by: 1
References: 58

Abstract

A cobalt-catalyzed enantioselective annulative dienylation of prochiral diarylmethyl amines with allenyl carbinol acetates via desymmetrization is reported. The method affords valuable C1-chiral 3-styryl-1,2-dihydroisoquinolines in high yields with excellent enantioselectivities. It is operationally simple and scalable, exhibits broad substrate generality, and is also effective for accessing P-stereogenic cyclic phosphinamides.

Fields of Study & Subjects

Asymmetric Hydrogenation and Catalysis Asymmetric Synthesis and Catalysis Axial and Atropisomeric Chirality Synthesis

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
19
Pages
6042–6047
Publication date
1 May 2026
Language
EN