Cu-Catalyzed Selective 1,5-Hydrophosphoro(di)thiolation of Vinyl Cyclopropanes

Organic Letters 2026

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Authors: Xuan Liu, Hanliang Zheng, Kai Hu, Wuyi Feng, Xinyao Shen, Chao Ma, Tao Cai
DOI: 10.1021/acs.orglett.6c01309
Cited by: 1
References: 42

Abstract

Herein, we report a copper-catalyzed selective 1,5-hydrophosphoro(di)thiolation of vinylcyclopropanes with various S -hydrogen phosphor(di)thioates without the need for a supported ligand. This protocol provides an efficient method for the preparation of structurally diverse homoallylic phosphorodithioates, featuring broad substrate scope and excellent regio- and stereoselectivity. Mechanistic investigations, including DFT calculations and XPS analysis, suggest that the CuBr catalyst acts as a Lewis acid, activating the S -hydrogen phosphorthioates via coordination reaction and promoting this transformation.

Fields of Study & Subjects

Sulfur-Based Synthesis Techniques Catalytic C–H Functionalization Methods Catalytic Alkyne Reactions

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
21
Pages
6546–6551
Publication date
17 May 2026
Language
EN